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Medical & Healthcare Franchise Opportunities Under $400k - Affordable Franchise Investment 2026

Explore proven Medical & Healthcare franchises under $400k across the USA and Canada. Find affordable, low-risk opportunities in home services, mobile businesses, cleaning, pet care, fitness, wellness, automotive, senior care, education, tutoring, kids’ activities, real estate services, marketing, retail, and food concepts. Compare investment ranges, fees, support, and territories. Ideal for entrepreneurs seeking a faster, lower-cost path to ownership in 2026
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Lice Lifters - Head Lice Removal
Medical & Healthcare Franchise Many Cities, Many States, USA

Lice Lifters - Head Lice Removal

Lice Lifters is one of America’s most recognized and trusted head-lice removal franchises, offering families fast, safe, and physician-recommended solutions during one of the most stressful moments of parenthood. Built on a science-driven, non-toxic treatment system and a warm, family-friendly se...

2010Estd.
10Units
Min. Investment

$85,000

Lice Clinics of America
Medical & Healthcare Franchise Many Cities, Many States, USA

Lice Clinics of America

Lice Clinics of America has emerged as one of the most trusted names in non-toxic lice treatment and prevention services across the United States. Built on innovation, scientific credibility, and a genuine commitment to family health, the brand has completely transformed what used to be a stressf...

2014Estd.
150Units
Min. Investment

$85,000

Let Mommy Sleep For Sale - Night Nurse & Newborn Care
Medical & Healthcare Franchise Many Cities, Many States, USA

Let Mommy Sleep For Sale - Night Nurse & Newborn Care

Let Mommy Sleep is one of America’s most trusted newborn care and overnight support brands, built on a simple yet powerful mission: to help families thrive during the exhausting early stages of parenthood. As sleep deprivation becomes a growing concern among new parents and postpartum care demand...

2010Estd.
20Units
Min. Investment

$75,000

In Home Personal Services
Medical & Healthcare Franchise Many Cities, Many States, USA

In Home Personal Services

In Home Personal Services is one of the most recognized names in the non-medical senior care sector, offering a compassionate, relationship-driven model that stands apart in an increasingly competitive home-care market. Built on the belief that seniors deserve independence, emotional support, and...

2000Estd.
20Units
Min. Investment

$75,000

Home Care for the 21st Century
Medical & Healthcare Franchise Many Cities, Many States, USA

Home Care for the 21st Century

Home Care for the 21st Century is one of America’s most comprehensive and forward-thinking home healthcare franchise opportunities. Built on the mission of providing complete, compassionate care for seniors and individuals in need of medical and non-medical assistance, this franchise has revoluti...

1996Estd.
50Units
Min. Investment

$89,500

Heritage Healthcare
Medical & Healthcare Franchise Many Cities, Many States, USA

Heritage Healthcare

When you choose to invest in the Heritage Healthcare franchise opportunity, you align yourself with a mission-driven brand built on trust, service, and strong operational foundations. Heritage Healthcare is more than just a business opportunity—it’s a platform for delivering compassionate home ca...

2008Estd.
19Units
Min. Investment

$150,000

Help Your Diabetes
Medical & Healthcare Franchise Many Cities, Many States, USA

Help Your Diabetes

Help Your Diabetes (HYD) is one of America’s most transformative healthcare franchise opportunities, offering entrepreneurs the chance to make a lasting difference in people’s lives while building a thriving business in a rapidly growing medical niche. The brand specializes in helping patients na...

2011Estd.
25Units
Min. Investment

$180,000

Health Atlast
Medical & Healthcare Franchise Many Cities, Many States, USA

Health Atlast

Health Atlast is redefining how Americans experience healthcare by merging the best of traditional medicine, chiropractic care, physical therapy, and wellness services under one roof. Founded by a passionate team of doctors, Health Atlast focuses on providing comprehensive and personalized treatm...

2012Estd.
10Units
Min. Investment

$150,000

GUAVA Senior Home and Healthcare Services opportunities
Medical & Healthcare Franchise Many Cities, Many States, USA & CAN

GUAVA Senior Home and Healthcare Services opportunities

GUAVA Senior Home and Healthcare Services is redefining the landscape of senior care in America. With an unwavering commitment to dignity, independence, and comfort, GUAVA provides high-quality non-medical and medical home care solutions designed to support seniors and individuals with special ne...

2012Estd.
50Units
Min. Investment

$100,000

Focus Point Behavioral Health
Medical & Healthcare Franchise Many Cities, Many States, USA

Focus Point Behavioral Health

Focus Point Behavioral Health is a trusted name in the growing mental health and wellness industry, providing compassionate and evidence-based behavioral health services to individuals and families across the United States. With a strong focus on personalized care, community impact, and accessibl...

2015Estd.
25Units
Min. Investment

$150,000

FLOSS Dental
Medical & Healthcare Franchise Many Cities, Many States, USA

FLOSS Dental

FLOSS Dental is redefining what Americans expect from their dental care experience. Founded with the vision of merging advanced technology, exceptional patient care, and sleek modern design, FLOSS Dental has become one of the most recognized names in cosmetic and general dentistry across the Unit...

2007Estd.
25Units
Min. Investment

$350,000

Florida Anesthesiology & Pain Clinic
Medical & Healthcare Franchise Many Cities, Many States, USA

Florida Anesthesiology & Pain Clinic

If you’re looking to invest in a healthcare brand that combines clinical excellence with a fast-growing wellness niche, consider the franchise opportunity offered by Florida Anesthesiology & Pain Clinic (FAPC). This is not just another clinic—it is a model built on delivering specialized pain...

1996Estd.
7Units
Min. Investment

$186,000

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